‘All disease begins in the gut’—the role of the intestinal microbiome in ankylosing spondylitis | Zendy

Patricia Harkins | Zendy; Eoghan Burke | Zendy; Catherine Swales | Zendy; Alan J. Silman | Zendy

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‘All disease begins in the gut’—the role of the intestinal microbiome in ankylosing spondylitis

Author(s) -

Patricia Harkins,

Eoghan Burke,

Catherine Swales,

Alan J. Silman

Publication year - 2021

Publication title -

rheumatology advances in practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 4

ISSN - 2514-1775

DOI - 10.1093/rap/rkab063

Subject(s) - ankylosing spondylitis , microbiome , pathogenesis , medicine , disease , spondylitis , gut microbiome , genetic predisposition , immunology , bioinformatics , intestinal microbiome , hla b27 , inflammatory bowel disease , pathology , biology , human leukocyte antigen , antigen

Ankylosing spondylitis is a chronic, debilitating arthritis with a predilection for the axial skeleton. It has a strong genetic predisposition, but the precise pathogenetic mechanisms involved in its development have not yet been fully elucidated. This has implications both for early diagnosis and for effective management. Recently, alterations in the intestinal microbiome have been implicated in disease pathogenesis. In this review, we summarize studies assessing the intestinal microbiome in AS pathogenesis, in addition to synthesizing the literature exploring the postulated mechanisms by which it exerts it pathogenic potential. Finally, we review studies analysing manipulation of the microbiome as a potential therapeutic avenue in AS management.

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