The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role | Zendy

Antonio Bertoletti | Zendy; Anthony T. Tan | Zendy; Nina Le Bert | Zendy

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The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role

Author(s) -

Antonio Bertoletti,

Anthony T. Tan,

Nina Le Bert

Publication year - 2021

Publication title -

oxford open immunology

Language(s) - English

Resource type - Journals

ISSN - 2633-6960

DOI - 10.1093/oxfimm/iqab006

Subject(s) - covid-19 , coronavirus , severe acute respiratory syndrome coronavirus , immunology , antibody , virology , coronaviridae , virus , betacoronavirus , immune system , medicine , immunity , biology , pathology , outbreak , disease , infectious disease (medical specialty)

SARS-CoV-2, the etiological agent of COVID-19, triggers an adaptive immunity in the infected host that results in the production of virus-specific antibodies and T cells. While kinetic and quantitative aspects of antibodies have been analyzed in large patient cohorts, similar information about SARS-CoV-2-specific T cells are scarce. We summarize in this review the available knowledge of quantitative and temporal features of the SARS-CoV-2 T cell response. Currently, most of the data derived only from the analysis of the circulatory compartment. Despite this limitation, early appearance, multi-specificity and functionality of SARS-CoV-2-specific T cells are associated with accelerated viral clearance and with protection from severe COVID-19.

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