Joint-Predominant Rheumatic Complications of Immune Checkpoint Inhibitor Therapy in Patients with Thymic Epithelial Tumors | Zendy

Cristina Mullenix | Zendy; Madison Ballman | Zendy; Haobin Chen | Zendy; Shan Swift | Zendy; Meredith J. McAdams | Zendy; Yo-Ting Tsai | Zendy; Renee N. Donahue | Zendy; Trina Poretta | Zendy; Sarthak Gupta | Zendy; Patrick J. Loehrer | Zendy; Jeffrey Schlom | Zendy; James L. Gulley | Zendy; Arun Rajan | Zendy

Open Access

Joint-Predominant Rheumatic Complications of Immune Checkpoint Inhibitor Therapy in Patients with Thymic Epithelial Tumors

Author(s) -

Cristina Mullenix,

Madison Ballman,

Haobin Chen,

Shan Swift,

Meredith J. McAdams,

Yo-Ting Tsai,

Renee N. Donahue,

Trina Poretta,

Sarthak Gupta,

Patrick J. Loehrer,

Jeffrey Schlom,

James L. Gulley,

Arun Rajan

Publication year - 2022

Publication title -

the oncologist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.176

H-Index - 164

eISSN - 1549-490X

pISSN - 1083-7159

DOI - 10.1093/oncolo/oyac026

Subject(s) - medicine , immune system , polymyalgia rheumatica , arthritis , thymoma , adverse effect , immunology , inflammation , vasculitis , disease , giant cell arteritis

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced cancers. However, activation of the immune system can occasionally cause life-threatening toxicity involving critical organs. Induction of immune-mediated toxicity is a significant concern for patients with thymic epithelial tumors (TETs) due to defects in immune tolerance. An increased risk of skeletal and cardiac muscle inflammation following treatment with ICIs is well recognized in patients with advanced TETs. However, uncommon musculoskeletal and rheumatic complications can also occur. The cases presented in this report highlight the spectrum of presentation of immune-mediated, joint-predominant musculoskeletal adverse events in patients with advanced TETs treated with ICIs, including polymyalgia rheumatica-like illness and inflammatory arthritis.

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