Antiretroviral Treatment Simplification With 2-Drug Regimens: Impact of Transmitted Drug Resistance Mutations | Zendy

Harald H. Kessler | Zendy; Evelyn Stelzl | Zendy; Anja Blažič | Zendy; Sanjay R. Mehta | Zendy; Anna S Benezeder | Zendy; Christina Genger-Hackl | Zendy; Brigitte I. Santner | Zendy; Antoine Chaillon | Zendy; Martin Hoenigl | Zendy

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Antiretroviral Treatment Simplification With 2-Drug Regimens: Impact of Transmitted Drug Resistance Mutations

Author(s) -

Harald H. Kessler,

Evelyn Stelzl,

Anja Blažič,

Sanjay R. Mehta,

Anna S Benezeder,

Christina Genger-Hackl,

Brigitte I. Santner,

Antoine Chaillon,

Martin Hoenigl

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz535

Subject(s) - medicine , drug , drug resistance , human immunodeficiency virus (hiv) , hiv drug resistance , antiretroviral therapy , pharmacology , virology , viral load , genetics , biology

The frequency of clinically relevant transmitted drug resistance mutations (DRMs) against drugs used for 2-drug regimens was 15.6%, but only 2% were not eligible for 1 or more 2-drug regimens. More than 50% of patients harboring any clinically relevant DRMs were found to be part of genetic transmission clusters.

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