Open AccessCorticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review
Author(s) -
Gregory S Canfield,
Andrés F. HenaoMartínez,
Carlos FrancoParedes,
Kristen Zhelnin,
Michael L. Wilson,
Katherine C Shihadeh,
David L. Wyles,
Edward M. Gardner
Publication year - 2019
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofz460
Subject(s) - cryptococcus gattii , meningoencephalitis , cryptococcosis , medicine , fluconazole , cryptococcus , immune system , immune reconstitution inflammatory syndrome , antifungal , pathogen , opportunistic pathogen , fungal pathogen , immunology , virology , microbiology and biotechnology , biology , dermatology , antiretroviral therapy , human immunodeficiency virus (hiv) , pseudomonas aeruginosa , viral load , genetics , bacteria
Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report successful maintenance phase treatment with isavuconazole, a novel triazole, following fluconazole-induced prolonged QT syndrome.