Open AccessSerum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report
Author(s) -
Martina Spaziante,
Cristiana Franchi,
Gloria Taliani,
Antonio D’Avolio,
Valeria Pietropaolo,
Elisa Biliotti,
Rozenn Esvan,
Mario Venditti
Publication year - 2019
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofz427
Subject(s) - medicine , dalbavancin , endocarditis , antibiotics , perioperative , staphylococcus aureus , surgery , vancomycin , microbiology and biotechnology , biology , bacteria , genetics
Here we describe a case of a methicillin-resistant coagulase-negative staphylococci prosthetic valve endocarditis in a patient considered not eligible for valve replacement due to high perioperative mortality risk and who did not tolerate oral antibiotic treatment. Under these circumstances, intravenous long-term chronic suppressive antibiotic therapy with dalbavancin, scheduling the doses using the serum bactericidal activity titers, proved to be safe and effective.