Open AccessBacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection
Author(s) -
Mi Sun Moon,
Gabriella Quinn,
Elizabeth Townsend,
Rabab Ali,
Grace Y Zhang,
Alyson Bradshaw,
Kareen Hill,
Hannah Guan,
Destanee Hamilton,
David E. Kleiner,
Christopher Koh,
Theo Heller
Publication year - 2019
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofz255
Subject(s) - peptidoglycan , chromosomal translocation , immune system , lipopolysaccharide , medicine , macrophage , immunology , microbiology and biotechnology , innate immune system , hepatitis c virus , virus , biology , bacteria , in vitro , biochemistry , genetics , gene
Hepatitis C virus (HCV) infects 71 million individuals, and barriers to treatment remain. Bacterial translocation is a complication of chronic HCV infection, and this study evaluated circulating microbial components including lipopolysaccharide, peptidoglycan, and β-D-glucan in addition to their pattern recognition receptors and degree of hepatic macrophage uptake. The findings suggest that regulation of serum peptidoglycan and β-D-glucan differs from that of lipopolysaccharide. Additionally, macrophage activation in the liver may be better reflected by the degree of macrophage uptake than by circulating levels of microbial markers. These findings allow for a greater understanding of bacterial translocation and host immune activation during HCV infection.