Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial | Zendy

MarieLaure Chaix | Zendy; Isabelle Charreau | Zendy; Claire Pintado | Zendy; Constance Delaugerre | Zendy; Nadia Mahjoub | Zendy; Laurent Cotte | Zendy; Catherine Capitant | Zendy; F. Raffi | Zendy; Éric Cua | Zendy; Gilles Pialoux | Zendy; Cécile Tremblay | Zendy; Laurence Meyer | Zendy; JeanMichel Molina | Zendy; Bénédicte Loze | Zendy; P Charbonneau | Zendy; Caroline Gatey | Zendy; Diane Ponscarme | Zendy; Pauline Penot | Zendy; Laurence Niedbalski | Zendy; R. Verón | Zendy; Juan F. Delgado | Zendy; Ernest Dallé | Zendy; S Parlier | Zendy; Isabelle Madelaine | Zendy; Julien Fonsart | Zendy; Marie Danet | Zendy; N Mezreb | Zendy; Khafil Moudachirou | Zendy; Stéphane Morel | Zendy; G Conort | Zendy; F Lorho | Zendy; M Meunier | Zendy; Willy Rozenbaum | Zendy; Julie Chas | Zendy; Christine Monfort | Zendy; J Foucoin | Zendy; B Boissavy | Zendy; S Cousseau | Zendy; S Huon | Zendy; A Djessima | Zendy; V Berrebi | Zendy; Anne Adda | Zendy; S. Le Nagat | Zendy; L. Zarka | Zendy; J Berdougo | Zendy; Christian Chidiac | Zendy; N. Mzoughi | Zendy; Fiona Clement | Zendy; A Decouty | Zendy; C Chapolard | Zendy; Matthieu Godinot | Zendy; C. Adouard-groslafeige | Zendy; J. Koffi | Zendy; Aymeric Pansu | Zendy; Ann De Becker | Zendy; Sophie Pailhes | Zendy; Fabrice Bonnet | Zendy; François Jeanblanc | Zendy; Céline BrochierArmanet | Zendy; X Teruin | Zendy; Soumaya El Rouby | Zendy; L Gilly | Zendy; C Etienne | Zendy; F Tolonin | Zendy; S Bréaud | Zendy; V Péchenot | Zendy; S Bagge | Zendy; T Cepitelli | Zendy; P. Roger | Zendy; E Rosenthal | Zendy; Antoine Chéret | Zendy; Pauline Cornavin | Zendy; Sarah Vandamme | Zendy; J Lambec | Zendy; N Dumon | Zendy; O Leclanche | Zendy; T. Huleux | Zendy; Raphaël Biekre | Zendy; Olivier Robineau | Zendy; Hugues Melliez | Zendy; H. Bazus | Zendy; A. Pasquet | Zendy; C Bernaud | Zendy; Michel Besnier | Zendy; B. Bonnet | Zendy; Nolwenn Hall | Zendy; M Cavellec | Zendy; H Hüe | Zendy; L Larmet | Zendy; Marina Vera Colás | Zendy; Rémy Choquet | Zendy; Catherine Beauvais | Zendy; Pascale Arlotto | Zendy; Claude Fortin | Zendy; Annie Talbot | Zendy; Annie Chamberland | Zendy; Andrew McKenzie | Zendy; Michael Blanchette | Zendy; Rodney Rousseau | Zendy; K Montheuth | Zendy; Joanne Otis | Zendy; David R. Thompson | Zendy; Michel Morin | Zendy; Mark A. Wainberg | Zendy; B Guillon | Zendy; Emmanuelle Netzer | Zendy; Nicolas Leturque | Zendy; J Binesse | Zendy; Valérie Foubert | Zendy; Marine Saouzanet | Zendy; F. Euphrasie | Zendy; Diane Carette | Zendy; J.-P. Aboulker | Zendy; Bruno Spire | Zendy; Luis SagaonTeyssier | Zendy; Marie Suzan | Zendy; Lisa Fressard | Zendy; Baptiste Demoulin | Zendy; G Cattin | Zendy; Nicolas Lorente | Zendy; Vincent Doré | Zendy; Lucie Marchand | Zendy; Soizic Le Mestre | Zendy; Anaïs Mennecier | Zendy; Elias Choucair | Zendy; Nicolas Etien | Zendy; Alpha Diallo | Zendy; Séverine Gibowski | Zendy; MarieChristine Simon | Zendy; Delfraissy Jf | Zendy; J M Le Gall | Zendy; A Djessima Taba | Zendy; B Dos Santos | Zendy; Vincent Coquelin | Zendy; Phillippe Brunet | Zendy; R Porion | Zendy; Daniela Rojas Castro | Zendy; Benoît Trottier | Zendy; JeanGuy Baril | Zendy; Nathalie Bajos | Zendy; Julie Timsit | Zendy; Gilles Peytavin | Zendy; Isabelle DurandZaleski | Zendy; J Aboulker | Zendy; Marie SuzanMonti | Zendy; Gabriel Girard | Zendy; Marie Préau | Zendy; Véronique Doré | Zendy; France Lert | Zendy; Cécile Rabian | Zendy

Open Access

Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

Author(s) -

MarieLaure Chaix,

Isabelle Charreau,

Claire Pintado,

Constance Delaugerre,

Nadia Mahjoub,

Laurent Cotte,

Catherine Capitant,

F. Raffi,

Éric Cua,

Gilles Pialoux,

Cécile Tremblay,

Laurence Meyer,

JeanMichel Molina,

Bénédicte Loze,

P Charbonneau,

Caroline Gatey,

Diane Ponscarme,

Pauline Penot,

Laurence Niedbalski,

R. Verón,

Juan F. Delgado,

Ernest Dallé,

S Parlier,

Isabelle Madelaine,

Julien Fonsart,

Marie Danet,

N Mezreb,

Khafil Moudachirou,

Stéphane Morel,

G Conort,

F Lorho,

M Meunier,

Willy Rozenbaum,

Julie Chas,

Christine Monfort,

J Foucoin,

B Boissavy,

S Cousseau,

S Huon,

A Djessima,

V Berrebi,

Anne Adda,

S. Le Nagat,

L. Zarka,

J Berdougo,

Christian Chidiac,

N. Mzoughi,

Fiona Clement,

A Decouty,

C Chapolard,

Matthieu Godinot,

C. Adouard-groslafeige,

J. Koffi,

Aymeric Pansu,

Ann De Becker,

Sophie Pailhes,

Fabrice Bonnet,

François Jeanblanc,

Céline BrochierArmanet,

X Teruin,

Soumaya El Rouby,

L Gilly,

C Etienne,

F Tolonin,

S Bréaud,

V Péchenot,

S Bagge,

T Cepitelli,

P. Roger,

E Rosenthal,

Antoine Chéret,

Pauline Cornavin,

Sarah Vandamme,

J Lambec,

N Dumon,

O Leclanche,

T. Huleux,

Raphaël Biekre,

Olivier Robineau,

Hugues Melliez,

H. Bazus,

A. Pasquet,

C Bernaud,

Michel Besnier,

B. Bonnet,

Nolwenn Hall,

M Cavellec,

H Hüe,

L Larmet,

Marina Vera Colás,

Rémy Choquet,

Catherine Beauvais,

Pascale Arlotto,

Claude Fortin,

Annie Talbot,

Annie Chamberland,

Andrew McKenzie,

Michael Blanchette,

Rodney Rousseau,

K Montheuth,

Joanne Otis,

David R. Thompson,

Michel Morin,

Mark A. Wainberg,

B Guillon,

Emmanuelle Netzer,

Nicolas Leturque,

J Binesse,

Valérie Foubert,

Marine Saouzanet,

F. Euphrasie,

Diane Carette,

J.-P. Aboulker,

Bruno Spire,

Luis SagaonTeyssier,

Marie Suzan,

Lisa Fressard,

Baptiste Demoulin,

G Cattin,

Nicolas Lorente,

Vincent Doré,

Lucie Marchand,

Soizic Le Mestre,

Anaïs Mennecier,

Elias Choucair,

Nicolas Etien,

Alpha Diallo,

Séverine Gibowski,

MarieChristine Simon,

Delfraissy Jf,

J M Le Gall,

A Djessima Taba,

B Dos Santos,

Vincent Coquelin,

Phillippe Brunet,

R Porion,

Daniela Rojas Castro,

Benoît Trottier,

JeanGuy Baril,

Nathalie Bajos,

Julie Timsit,

Gilles Peytavin,

Isabelle DurandZaleski,

J Aboulker,

Marie SuzanMonti,

Gabriel Girard,

Marie Préau,

Véronique Doré,

France Lert,

Cécile Rabian

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy295

Subject(s) - medicine , emtricitabine , pre exposure prophylaxis , incidence (geometry) , placebo , herpes simplex virus , men who have sex with men , population , tenofovir , virology , viral load , human immunodeficiency virus (hiv) , virus , antiretroviral therapy , environmental health , syphilis , physics , alternative medicine , pathology , optics

We evaluated the impact of on-demand oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) on herpes simplex virus (HSV)-1/2 incidence among men who have sex with men (MSM) enrolled in the ANRS IPERGAY trial. Serum samples were tested at baseline and at the last visit for HSV-1/2 antibodies. Overall HSV-1 incidence was 11.7 per 100 person-years; 16.2 and 7.8 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .19). Overall HSV-2 incidence was 7.6 per 100 person-years; 8.1 and 7.0 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .75). On-demand oral PrEP with TDF/FTC failed to reduce HSV-1/2 incidence in this population.

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