Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir | Zendy

Jomy George | Zendy; Safia Kuriakose | Zendy; Nicola Dee | Zendy; Pam Stoll | Zendy; Tahaniyat Lalani | Zendy; Robin Dewar | Zendy; Muhammad Attique Khan | Zendy; M. Tauseef Rehman | Zendy; Zehava Grossman | Zendy; Frank Maldarelli | Zendy; Alice K. Pau | Zendy

Open Access

Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir

Author(s) -

Jomy George,

Safia Kuriakose,

Nicola Dee,

Pam Stoll,

Tahaniyat Lalani,

Robin Dewar,

Muhammad Attique Khan,

M. Tauseef Rehman,

Zehava Grossman,

Frank Maldarelli,

Alice K. Pau

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy221

Subject(s) - dolutegravir , medicine , baseline (sea) , mutation , virology , genetics , human immunodeficiency virus (hiv) , biology , viral load , antiretroviral therapy , gene , fishery

HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.

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