Open AccessRapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir
Author(s) -
Jomy George,
Safia Kuriakose,
Nicola Dee,
Pam Stoll,
Tahaniyat Lalani,
Robin Dewar,
Muhammad Attique Khan,
Muhammad T Rehman,
Zehava Grossman,
Frank Maldarelli,
Alice Pau
Publication year - 2018
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofy221
Subject(s) - dolutegravir , medicine , baseline (sea) , mutation , virology , genetics , human immunodeficiency virus (hiv) , biology , viral load , antiretroviral therapy , gene , fishery
HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.