The Association of Human Leukocyte Antigen and COVID-19 in Southern China | Zendy

Xueping Yu | Zendy; Kuo-Ting Ho | Zendy; Zhongliang Shen | Zendy; Xiaoying Fu | Zendy; Hongbo Huang | Zendy; Delun Wu | Zendy; Yancheng Lin | Zendy; Yijian Lin | Zendy; Wenhuang Chen | Zendy; Milong Su | Zendy; Chao Qiu | Zendy; Xibin Zhuang | Zendy; Zhijun Su | Zendy

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The Association of Human Leukocyte Antigen and COVID-19 in Southern China

Author(s) -

Xueping Yu,

Kuo-Ting Ho,

Zhongliang Shen,

Xiaoying Fu,

Hongbo Huang,

Delun Wu,

Yancheng Lin,

Yijian Lin,

Wenhuang Chen,

Milong Su,

Chao Qiu,

Xibin Zhuang,

Zhijun Su

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab410

Subject(s) - human leukocyte antigen , immunology , antigen , allele , medicine , immune system , virology , covid-19 , infectious disease (medical specialty) , disease , biology , genetics , gene , pathology

Human leukocyte antigen (HLA) polymorphism is hypothesized to be associated with diverse immune responses toward infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and HLA-DRB1*04:06 were associated with coronavirus disease 2019 susceptibility in China. Both alleles were predicted to have weak binding affinities toward viral proteins.

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