Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study | Zendy

Issei Oi | Zendy; Isao Ito | Zendy; Masataka Hirabayashi | Zendy; Kazuo Endo | Zendy; Masahito Emura | Zendy; Toru Kojima | Zendy; Hitokazu Tsukao | Zendy; Keisuke Tomii | Zendy; Atsushi Nakagawa | Zendy; Kojiro Otsuka | Zendy; Masaya Akai | Zendy; Masahiro Oi | Zendy; Takakazu Sugita | Zendy; Motonari Fukui | Zendy; Daiki Inoue | Zendy; Yoshinori Hasegawa | Zendy; Ken­ichi Takahashi | Zendy; Hiroaki Yasui | Zendy; Kohei Fujita | Zendy; Tadashi Ishida | Zendy; Akihiro Ito | Zendy; Hideo Kita | Zendy; Yusuke Kaji | Zendy; Michiko Tsuchiya | Zendy; Hiromi Tomioka | Zendy; Takashi Yamada | Zendy; Satoru Terada | Zendy; Hitoshi Nakaji | Zendy; Nobuyoshi Hamao | Zendy; Masahiro Shirata | Zendy; Kensuke Nishioka | Zendy; Masatoshi Yamazoe | Zendy; Yusuke Shiraishi | Zendy; Tatsuya Ogimoto | Zendy; Kazutaka Hosoya | Zendy; Hitomi Ajimizu | Zendy; Hiroshi Shima | Zendy; Hisako Matsumoto | Zendy; Naoya Tanabe | Zendy; Toyohiro Hirai | Zendy

Open Access

Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study

Author(s) -

Issei Oi,

Isao Ito,

Masataka Hirabayashi,

Kazuo Endo,

Masahito Emura,

Toru Kojima,

Hitokazu Tsukao,

Keisuke Tomii,

Atsushi Nakagawa,

Kojiro Otsuka,

Masaya Akai,

Masahiro Oi,

Takakazu Sugita,

Motonari Fukui,

Daiki Inoue,

Yoshinori Hasegawa,

Kenichi Takahashi,

Hiroaki Yasui,

Kohei Fujita,

Tadashi Ishida,

Akihiro Ito,

Hideo Kita,

Yusuke Kaji,

Michiko Tsuchiya,

Hiromi Tomioka,

Takashi Yamada,

Satoru Terada,

Hitoshi Nakaji,

Nobuyoshi Hamao,

Masahiro Shirata,

Kensuke Nishioka,

Masatoshi Yamazoe,

Yusuke Shiraishi,

Tatsuya Ogimoto,

Kazutaka Hosoya,

Hitomi Ajimizu,

Hiroshi Shima,

Hisako Matsumoto,

Naoya Tanabe,

Toyohiro Hirai

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab282

Subject(s) - medicine , pneumonia , coronavirus , virology , covid-19 , viral pneumonia , virus , respiratory system , influenza a virus , intensive care medicine , outbreak , infectious disease (medical specialty) , disease

Background Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear. Methods A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP. Results Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P < .01), lower neutrophil-to-lymphocyte ratio (P < .01), lower systolic blood pressure (P < .01), higher diastolic blood pressure (P < .01), lower aspartate aminotransferase level (P < .05), higher serum sodium level (P < .05), and more frequent multilobar infiltrates (P < .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP. Conclusions Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings.

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