Open AccessDisseminated Gonococcal Infection Complicated by Prosthetic Joint Infection: Case Report and Genomic and Phylogenetic Analysis
Author(s) -
Osakpolor Ogbebor,
Tatum D Mortimer,
Kyra E Fryling,
Jessica J Zhang,
Nitin Bhanot,
Yonatan H. Grad
Publication year - 2020
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofaa632
Subject(s) - neisseria gonorrhoeae , phylogenetic tree , lineage (genetic) , medicine , whole genome sequencing , virulence , antibiotic resistance , outbreak , gonococcal infection , biology , virology , antibiotics , gene , genome , microbiology and biotechnology , genetics , sexually transmitted disease , syphilis , human immunodeficiency virus (hiv)
Neisseria gonorrhoeae infections have been increasing globally, with prevalence rising across age groups. In this study, we report a case of disseminated gonococcal infection (DGI) involving a prosthetic joint, and we use whole-genome sequencing to characterize resistance genes, putative virulence factors, and the phylogenetic lineage of the infecting isolate. We review the literature on sequence-based prediction of antibiotic resistance and factors that contribute to risk for DGI. We argue for routine sequencing and reporting of invasive gonococcal infections to aid in determining whether an invasive gonococcal infection is sporadic or part of an outbreak and to accelerate understanding of the genetic features of N gonorrhoeae that contribute to pathogenesis.