Longitudinal Progression of Subclinical Coronary Atherosclerosis in Swiss HIV-Positive Compared With HIV-Negative Persons Undergoing Coronary Calcium Score Scan and CT Angiography | Zendy

Philip Tarr | Zendy; Bruno Ledergerber | Zendy; Alexandra Calmy | Zendy; Thanh DocoLecompte | Zendy; Isabella C Schoepf | Zendy; Alex Marzel | Zendy; Rainer Weber | Zendy; Philipp A. Kaufmann | Zendy; René Nkoulou | Zendy; Ronny R. Buechel | Zendy; Helen Kovari | Zendy; A Anagnostopoulos | Zendy; M Battegay | Zendy; Enos Bernasconi | Zendy; J Böni | Zendy; Dominique L. Braun | Zendy; H C Bucher | Zendy; Matthias Cavassini | Zendy; Angela Ciuffi | Zendy; G Dollenmaier | Zendy; Matthias Egger | Zendy; Luigia Elzi | Zendy; J Fehr | Zendy; Jacques Fellay | Zendy; H Furrer | Zendy; C A Fux | Zendy; Huldrych F. Günthard | Zendy; David Haerry | Zendy; Barbara Hasse | Zendy; Hans H. Hirsch | Zendy; Marc Hoffmann | Zendy; Irène Hösli | Zendy; M. Huber | Zendy; Christian R. Kahlert | Zendy; Laurent Kaiser | Zendy; Olivia Keiser | Zendy; Thomas Klimkait | Zendy; Roger D. Kouyos | Zendy; G Martinetti | Zendy; Begoña Martínez de Tejada | Zendy; Catia Marzolini | Zendy; Karin J. Metzner | Zendy; Nicolas Müller | Zendy; Dunja Nicca | Zendy; P Paioni | Zendy; Giuseppe Pantaleo | Zendy; Matthieu Perreau | Zendy; Andri Rauch | Zendy; Charles M. Rudin | Zendy; Alexandra Scherrer | Zendy; Patrick Schmid | Zendy; Roberto F. Speck | Zendy; M Stöckle | Zendy; Alexandra Trkola | Zendy; P Vernazza | Zendy; Gilles Wandeler | Zendy; Sabine Yerly | Zendy

Open Access

Longitudinal Progression of Subclinical Coronary Atherosclerosis in Swiss HIV-Positive Compared With HIV-Negative Persons Undergoing Coronary Calcium Score Scan and CT Angiography

Author(s) -

Philip Tarr,

Bruno Ledergerber,

Alexandra Calmy,

Thanh DocoLecompte,

Isabella C Schoepf,

Alex Marzel,

Rainer Weber,

Philipp A. Kaufmann,

René Nkoulou,

Ronny R. Buechel,

Helen Kovari,

A Anagnostopoulos,

M Battegay,

Enos Bernasconi,

J Böni,

Dominique L. Braun,

H C Bucher,

Matthias Cavassini,

Angela Ciuffi,

G Dollenmaier,

Matthias Egger,

Luigia Elzi,

J Fehr,

Jacques Fellay,

H Furrer,

C A Fux,

Huldrych F. Günthard,

David Haerry,

Barbara Hasse,

Hans H. Hirsch,

Marc Hoffmann,

Irène Hösli,

M. Huber,

Christian R. Kahlert,

Laurent Kaiser,

Olivia Keiser,

Thomas Klimkait,

Roger D. Kouyos,

G Martinetti,

Begoña Martínez de Tejada,

Catia Marzolini,

Karin J. Metzner,

Nicolas Müller,

Dunja Nicca,

P Paioni,

Giuseppe Pantaleo,

Matthieu Perreau,

Andri Rauch,

Charles M. Rudin,

Alexandra Scherrer,

Patrick Schmid,

Roberto F. Speck,

M Stöckle,

Alexandra Trkola,

P Vernazza,

Gilles Wandeler,

Sabine Yerly

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa438

Subject(s) - medicine , interquartile range , subclinical infection , human immunodeficiency virus (hiv) , coronary calcium score , multicenter aids cohort study , cardiology , framingham risk score , coronary artery calcium , viral load , coronary artery disease , immunology , antiretroviral therapy , disease

Background People with HIV (HIV+) may have increased cardiovascular event rates compared with HIV-negative (HIV-) persons. Cross-sectional data from the United States and Switzerland, based on coronary artery calcium scan (CAC) and coronary computed tomography angiography (CCTA), suggest, respectively, increased and similar prevalence of subclinical atherosclerosis in HIV+ vs HIV- persons. Methods We repeated CAC/CCTA in 340 HIV+ and 90 HIV- study participants >2 years after baseline CAC/CCTA. We assessed the association of HIV infection, Framingham risk score (FRS), and HIV-related factors with the progression of subclinical atherosclerosis. Results HIV+ were younger than HIV- participants (median age, 52 vs 56 years; P < .01) but had similar median 10-year FRS (8.9% vs 9.0%; P = .82); 94% had suppressed HIV viral load. In univariable and multivariable analyses, FRS was associated with the incidence rate ratio (IRR) of new subclinical atherosclerosis at the follow-up CAC/CCTA, but HIV infection was not: any plaque (adjusted IRR for HIV+ vs HIV- participants, 1.21; 95% CI, 0.62–2.35), calcified plaque (adjusted IRR for HIV+ vs HIV- participants, 1.06; 95% CI, 0.56–2), noncalcified/mixed plaque (adjusted IRR for HIV+ vs HIV- participants, 1.24; 95% CI, 0.69–2.21), and high-risk plaque (adjusted IRR for HIV+ vs HIV- participants, 1.46; 95% CI, 0.66–3.20). Progression of CAC score between baseline and follow-up CAC/CCTA was similar in HIV+ (median annualized change [interquartile range {IQR}], 0.41 [0–10.19]) and HIV- participants (median annualized change [IQR], 2.38 [0–16.29]; P = .11), as was progression of coronary segment severity score (HIV+: median annualized change [IQR], 0 [0–0.47]; HIV-: median annualized change [IQR], 0 [0–0.52]; P = .10) and coronary segment involvement score (HIV+: median annualized change [IQR], 0 [0–0.45]; HIV-: median annualized change [IQR], 0 [0–0.41]; P = .25). Conclusions In this longitudinal CAC/CCTA study from Switzerland, Framingham risk score was associated with progression of subclinical atherosclerosis, but HIV infection was not.

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