Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China | Zendy

Shuang Xu | Zendy; Fei Shao | Zendy; Banghe Bao | Zendy; Xuedi Ma | Zendy; Zhouming Xu | Zendy; Jiwen You | Zendy; Peng Zhao | Zendy; Yuwei Liu | Zendy; Michael Ng | Zendy; Hao Cui | Zendy; Changxiao Yu | Zendy; Qing Zhang | Zendy; Dandan Li | Zendy; Ziren Tang | Zendy; Peng Sun | Zendy

Open Access

Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Author(s) -

Shuang Xu,

Fei Shao,

Banghe Bao,

Xuedi Ma,

Zhouming Xu,

Jiwen You,

Peng Zhao,

Yuwei Liu,

Michael Ng,

Hao Cui,

Changxiao Yu,

Qing Zhang,

Dandan Li,

Ziren Tang,

Peng Sun

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa283

Subject(s) - medicine , pregnancy , asymptomatic , pneumonia , obstetrics , apgar score , covid-19 , erythrocyte sedimentation rate , disease , pediatrics , fetus , infectious disease (medical specialty) , genetics , biology

Background Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China. Methods We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to 40, admitted between January 15 and March 15, 2020 at Union Hospital, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1. Results Among 64 patients, 34 (53.13%) were pregnant, with higher proportion of exposure history (29.41% vs 6.67%) and more pulmonary infiltration on computed tomography test (50% vs 10%) compared to nonpregnant women. Of pregnant patients, 27 (79.41%) completed pregnancy, 5 (14.71%) had natural delivery, 18 (52.94%) had cesarean section, and 4 (11.76%) had abortion; 5 (14.71%) patients were asymptomatic. All 23 newborns had negative reverse-transcription polymerase chain results, and an average 1-minute Apgar score was 8–9 points. Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration, and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1. Conclusions Clinical characteristics of pregnant patients with COVID-19 are less serious than nonpregnant. No evidence indicated that pregnant women may have fetal infection through vertical transmission of COVID-19. Pregnant patients with H1N1 had more serious condition than those with COVID-19.

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