Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test | Zendy

Gautam Kalyatanda | Zendy; Kenneth H. Rand | Zendy; Martin Lindner | Zendy; David K. Hong | Zendy; Sait Albayram | Zendy; Jason V. Gregory | Zendy; Jesse Kresak | Zendy; Karim M Ali Ibne | Zendy; Jennifer R. Cope | Zendy; Shantanu Roy | Zendy; Joy Gary | Zendy; Varalakshmi Ballur Narayana Reddy | Zendy; Asim A. Ahmed | Zendy

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Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test

Author(s) -

Gautam Kalyatanda,

Kenneth H. Rand,

Martin Lindner,

David K. Hong,

Sait Albayram,

Jason V. Gregory,

Jesse Kresak,

Karim M Ali Ibne,

Jennifer R. Cope,

Shantanu Roy,

Joy Gary,

Varalakshmi Ballur Narayana Reddy,

Asim A. Ahmed

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa189

Subject(s) - medicine , brain biopsy , encephalitis , pathology , autopsy , dna sequencing , virology , biopsy , dna , biology , virus , genetics

Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.

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