Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia | Zendy

Rachel Jesus Cruz | Zendy; Joseph Dasso | Zendy; Carla Duff | Zendy; Diane Krasnopero | Zendy; Zsofia Long | Zendy; Maryssa Ellison | Zendy; Daime Nieves | Zendy; Panida Sriaroon | Zendy; Alfred AsanteKorang | Zendy; Jolán E. Walter | Zendy

Open Access

Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia

Author(s) -

Rachel Jesus Cruz,

Joseph Dasso,

Carla Duff,

Diane Krasnopero,

Zsofia Long,

Maryssa Ellison,

Daime Nieves,

Panida Sriaroon,

Alfred AsanteKorang,

Jolán E. Walter

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa076

Subject(s) - medicine , viremia , parvovirus , aseptic meningitis , antibody , hyaluronidase , immunology , gastroenterology , meningitis , surgery , virus , biochemistry , chemistry , enzyme

We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.

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