Open AccessEffects of Reduced Nicotine Content Cigarettes on Fractional Exhaled Nitric Oxide and Self-Reported Respiratory Health Outcomes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage
Author(s) -
Anthony Oliver,
Michael DeSarno,
Charles G. Irvin,
David A. Kaminsky,
Jennifer W. Tidey,
Stacey C. Sigmon,
Sarah H. Heil,
Diann E. Gaalema,
Dustin Lee,
Janice Y. Bunn,
Danielle R. Davis,
Joanna M. Streck,
Thomas J. Gallagher,
Stephen T. Higgins
Publication year - 2021
Publication title -
nicotine and tobacco research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 113
eISSN - 1469-994X
pISSN - 1462-2203
DOI - 10.1093/ntr/ntab145
Subject(s) - exhaled nitric oxide , medicine , nicotine , socioeconomic status , respiratory system , cotinine , asthma , environmental health , population , spirometry
This study examined whether exposure to reduced-nicotine-content cigarettes (RNCCs) for 12 weeks alters respiratory health using Fractional Exhaled Nitric Oxide (FeNO), a validated biomarker of respiratory epithelial health, and the Respiratory Health Questionnaire (RHQ), a subject-rated questionnaire on respiratory symptoms. Participants were 747 adult daily smokers enrolled in three double-blind, randomized clinical trials evaluating effects of cigarette nicotine content (0.4, 2.4, 15.8 mg nicotine/g tobacco) in people with affective disorders, opioid use disorder (OUD), or socioeconomic disadvantage.