Open AccessRewarding Effects of Nicotine Self-administration Increase Over Time in Male and Female Rats
Author(s) -
Ranjithkumar Chellian,
Azin BehnoodRod,
Ryann Wilson,
Adrie W. Bruijnzeel
Publication year - 2021
Publication title -
nicotine and tobacco research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 113
eISSN - 1469-994X
pISSN - 1462-2203
DOI - 10.1093/ntr/ntab097
Subject(s) - nicotine , mecamylamine , self administration , brain stimulation reward , alkaloid , medicine , nicotinic agonist , stimulation , nicotine withdrawal , psychology , antagonist , pharmacology , anesthesia , receptor , nucleus accumbens , biology , botany
Smoking and the use of other nicotine-containing products is rewarding in humans. The self-administration of nicotine is also rewarding in male rats. However, it is unknown if there are sex differences in the reward-enhancing effects of nicotine self-administration and if the rewarding effects of nicotine change over time.