Open AccessGenetic and Depressive Traits Moderate the Reward-Enhancing Effects of Acute Nicotine in Young Light Smokers
Author(s) -
Alexis E. Whitton,
Norka E. Rabinovich,
John D Lindt,
Michele L. Pergadia,
Diego A. Pizzagalli,
David G. Gilbert
Publication year - 2021
Publication title -
nicotine and tobacco research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 113
eISSN - 1469-994X
pISSN - 1462-2203
DOI - 10.1093/ntr/ntab072
Subject(s) - nicotine , placebo , allele , psychology , big five personality traits , smoking cessation , medicine , personality , psychiatry , genetics , biology , social psychology , alternative medicine , pathology , gene
Rates of light smoking have increased in recent years and are associated with adverse health outcomes. Reducing light smoking is a challenge because it is unclear why some but not others, progress to heavier smoking. Nicotine has profound effects on brain reward systems and individual differences in nicotine's reward-enhancing effects may drive variability in smoking trajectories. Therefore, we examined whether a genetic risk factor and personality traits known to moderate reward processing, also moderate the reward-enhancing effects of nicotine.