Exenatide Adjunct to Nicotine Patch Facilitates Smoking Cessation and May Reduce Post-Cessation Weight Gain: A Pilot Randomized Controlled Trial | Zendy

Luba Yammine | Zendy; Charles E. Green | Zendy; Thomas R. Kosten | Zendy; Constanza de Dios | Zendy; Robert Suchting | Zendy; Scott D. Lane | Zendy; Christopher D. Verrico | Zendy; Joy M. Schmitz | Zendy

Open Access

Exenatide Adjunct to Nicotine Patch Facilitates Smoking Cessation and May Reduce Post-Cessation Weight Gain: A Pilot Randomized Controlled Trial

Author(s) -

Luba Yammine,

Charles E. Green,

Thomas R. Kosten,

Constanza de Dios,

Robert Suchting,

Scott D. Lane,

Christopher D. Verrico,

Joy M. Schmitz

Publication year - 2021

Publication title -

nicotine and tobacco research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.338

H-Index - 113

eISSN - 1469-994X

pISSN - 1462-2203

DOI - 10.1093/ntr/ntab066

Subject(s) - adjunct , smoking cessation , medicine , randomized controlled trial , nicotine , nicotine patch , physical therapy , psychiatry , alternative medicine , placebo , philosophy , linguistics , pathology

Approved pharmacological treatments for smoking cessation are modestly effective, underscoring the need for improved pharmacotherapies. Glucagon-like peptide-1 receptor (GLP-1R) agonists attenuate the rewarding effects of nicotine in preclinical studies. We examined the efficacy of extended-release exenatide, a GLP-1R agonist, combined with nicotine replacement therapy (NRT, patch) for smoking cessation, craving, and withdrawal symptoms, with post-cessation body weight as a secondary outcome.

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