Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers | Zendy

Xianghua Luo | Zendy; Steven G. Carmella | Zendy; Menglan Chen | Zendy; Joni Jensen | Zendy; Lynne R. Wilkens | Zendy; Loı̈c Le Marchand | Zendy; Dorothy K. Hatsukami | Zendy; Sharon E. Murphy | Zendy; Stephen S. Hecht | Zendy

Open Access

Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers

Author(s) -

Xianghua Luo,

Steven G. Carmella,

Menglan Chen,

Joni Jensen,

Lynne R. Wilkens,

Loı̈c Le Marchand,

Dorothy K. Hatsukami,

Sharon E. Murphy,

Stephen S. Hecht

Publication year - 2020

Publication title -

nicotine and tobacco research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.338

H-Index - 113

eISSN - 1469-994X

pISSN - 1462-2203

DOI - 10.1093/ntr/ntaa080

Subject(s) - cotinine , urine , smokeless tobacco , acrylonitrile , nicotine , menthol , mercapturic acid , toxicant , urinary system , biomarker , medicine , tobacco smoke , metabolite , physiology , toxicology , chemistry , environmental health , toxicity , tobacco use , biochemistry , biology , population , organic chemistry , cysteine , copolymer , enzyme , polymer

Cyanoethyl mercapturic acid (CEMA) is a urinary metabolite of acrylonitrile, a toxicant found in substantial quantities in cigarette smoke, but not in non-combusted products such as e-cigarettes or smokeless tobacco and rarely in the diet or in the general human environment. Thus, we hypothesized that CEMA is an excellent biomarker of combusted tobacco product use.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research