Open AccessBDNF, COMT, and DRD2 polymorphisms and ability to return to work in adult patients with low- and high-grade glioma
Author(s) -
David Altshuler,
Lin Wang,
Lili Zhao,
Zachary Miklja,
Joey Linzey,
Amanda Brezzell,
Sofia Kakaizada,
Saritha Krishna,
Daniel A. Orringer,
Emily M. Briceño,
Nicolette Gabel,
Shawn Hervey-Jumper
Publication year - 2019
Publication title -
neuro-oncology practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 14
eISSN - 2054-2585
pISSN - 2054-2577
DOI - 10.1093/nop/npy059
Subject(s) - rs4680 , neurocognitive , rs6265 , repeatable battery for the assessment of neuropsychological status , stroop effect , medicine , oncology , neuropsychology , trail making test , glioma , catechol o methyl transferase , cognition , brain derived neurotrophic factor , neurotrophic factors , clinical psychology , psychology , allele , psychiatry , biology , genetics , receptor , cancer research , gene
Cognitive and language dysfunction is common among patients with glioma and has a significant impact on survival and health-related quality of life (HRQOL). Little is known about the factors that make individual patients more or less susceptible to the cognitive sequelae of the disease. A better understanding of the individual and population characteristics related to cognitive function in glioma patients is required to appropriately stratify patients, prognosticate, and develop more efficacious treatment regimens. There is evidence that allelic variation among genes involved in neurotransmission and synaptic plasticity are related to neurocognitive performance in states of health and neurologic disease.