Open AccessWhole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1
Author(s) -
Abigail Godec,
Reyka G. Jayasinghe,
John S.A. Chrisinger,
Bethany C. Prudner,
Tyler Ball,
Yuxi Wang,
Divya Srihari,
Madhurima Kaushal,
Hilary Dietz,
Xiaochun Zhang,
Melike Pekmezci,
Sonika Dahiya,
Tao Yu,
Jingqin Luo,
Brian A. Van Tine,
Ding Li,
David H. Gutmann,
Angela C. Hirbe
Publication year - 2019
Publication title -
neuro-oncology advances
Language(s) - English
Resource type - Journals
ISSN - 2632-2498
DOI - 10.1093/noajnl/vdz026
Subject(s) - exome sequencing , exome , medicine , pathology , malignant peripheral nerve sheath tumor , peripheral blood , peripheral , peripheral nerve , primary tumor , metastasis , cancer research , biology , anatomy , immunohistochemistry , cancer , mutation , genetics , gene
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas with high metastatic rates and poor overall patient survival. There are currently no effective therapies, underscoring the pressing need to define the molecular etiologies that underlie MPNST progression. The aim of this study was to examine clonal progression and identify the molecular events critical for MPNST spread.