Open AccessNatural History and Pathophysiology of Arteriovenous Malformations
Author(s) -
W J Michelsen
Publication year - 1979
Publication title -
neurosurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.485
H-Index - 34
eISSN - 1081-1281
pISSN - 0148-396X
DOI - 10.1093/neurosurgery/26.cn_suppl_1.307
Subject(s) - medicine , macrocephaly , natural history , hydrocephalus , pathophysiology , pediatrics , epilepsy , subarachnoid hemorrhage , central nervous system , surgery , pathology , psychiatry
AVMs are congenital malformations of central nervous system blood vessels. The majority of lesions become symptomatic prior to age 40. Hemorrhage and epilepsy are the most frequent presenting symptoms. Disabling headache, transient, progressive, and permanent neurological deficit, heart failure, hydrocephalus, macrocephaly, and intellectual impairment may also occur. Long-term mortality is approximately 18%, and morbidity leading to disability occurs in 30% of patients. Aggressive management when possible is indicated.