Open AccessA Clinical Rule for Preoperative Prediction of BRAF Mutation Status in Craniopharyngiomas
Author(s) -
Fujio Shimizu,
Tareq A. Juratli,
Kazunori Arita,
Hirofumi Hirano,
Yoshiyuki Nagano,
Tomoko Takajo,
Koji Yoshimoto,
Ivanna V. Bihun,
Alexander Kaplan,
Naema Nayyar,
Alex Fink,
Mia Bertalan,
Shilpa S. Tummala,
William T. Curry,
Pamela S. Jones,
María Martínez-Lage,
Daniel P. Cahill,
Fred G. Barker,
Priscilla K. Brastianos
Publication year - 2018
Publication title -
neurosurgery/neurosurgery online
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.485
H-Index - 34
eISSN - 1081-1281
pISSN - 0148-396X
DOI - 10.1093/neuros/nyy569
Subject(s) - medicine , craniopharyngioma , cohort , mutation , retrospective cohort study , oncology , calcification , radiology , genetics , biology , gene
Papillary craniopharyngiomas are characterized by BRAFV600E mutations. Targeted therapy can elicit a dramatic radiographic regression of these tumors. Therefore, prediction of BRAF mutation status before definitive surgery could enable neoadjuvant treatment strategies.