Open AccessFolate Receptor Overexpression in Human and Canine Meningiomas—Immunohistochemistry and Case Report of Intraoperative Molecular Imaging
Author(s) -
J. Thomas Pierce,
Steve S. Cho,
Shayoni Nag,
Ryan Zeh,
Jun Jeon,
David E. Holt,
Amy C. Durham,
MacLean P. Nasrallah,
Sunil Singhal
Publication year - 2018
Publication title -
neurosurgery/neurosurgery online
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.455
H-Index - 198
eISSN - 1081-1281
pISSN - 0148-396X
DOI - 10.1093/neuros/nyy356
Subject(s) - medicine , meningioma , immunohistochemistry , pathology , dura mater , folate receptor , radiology , cancer , cancer cell
Meningiomas are well-encapsulated benign brain tumors and surgical resection is often curative. Nevertheless, this is not always possible due to the difficulty of identifying residual disease intraoperatively. We hypothesized that meningiomas overexpress folate receptor alpha (FRα), allowing intraoperative molecular imaging by targeting FRα with a near-infrared (NIR) dye.