Open AccessPercutaneous Trigeminal Nerve Stimulation Induces Cerebral Vasodilation in a Dose-Dependent Manner
Author(s) -
Chunyan Li,
Timothy G White,
Kevin Shah,
Wayne Chaung,
Keren Powell,
Haichao Wang,
Henry H. Woo,
Raj K. Narayan
Publication year - 2021
Publication title -
neurosurgery/neurosurgery online
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.455
H-Index - 198
eISSN - 1081-1281
pISSN - 0148-396X
DOI - 10.1093/neuros/nyab053
Subject(s) - medicine , vasodilation , anesthesia , cerebral blood flow , cerebral perfusion pressure , calcitonin gene related peptide , cerebral circulation , subarachnoid hemorrhage , cerebral vasospasm , vasospasm , neuropeptide , receptor
The trigeminal nerve directly innervates key vascular structures both centrally and peripherally. Centrally, it is known to innervate the brainstem and cavernous sinus, whereas peripherally the trigemino-cerebrovascular network innervates the majority of the cerebral vasculature. Upon stimulation, it permits direct modulation of cerebral blood flow (CBF), making the trigeminal nerve a promising target for the management of cerebral vasospasm. However, trigeminally mediated cerebral vasodilation has not been applied to the treatment of vasospasm.