Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort | Zendy

Shubha S. Bellur | Zendy; Stephen A. Roberts | Zendy; Stéphan Troyanov | Zendy; Virginie Royal | Zendy; Rosanna Coppo | Zendy; H. Terence Cook | Zendy; Daniel C. Cattran | Zendy; Y. Arce Terroba | Zendy; Anna Maria Asunis | Zendy; Ingeborg M. Bajema | Zendy; E. Bertoni | Zendy; Jan A. Bruijn | Zendy; Pablo CannataOrtiz | Zendy; Donatella Casartelli | Zendy; Anna Maria Di Palma | Zendy; Franco Ferrario | Zendy; Mirella Fortunato | Zendy; Luciana Furci | Zendy; Hariklia Gakiopoulou | Zendy; Danica Galešić Ljubanović | Zendy; Konstantinos Giannakakis | Zendy; Montserrat GomàiFreixanet | Zendy; Hermann-Josef Gröne | Zendy; Eduardo Gutiérrez | Zendy; Syeda Asma Haider | Zendy; Eva Honsová | Zendy; E. Ioachim | Zendy; Henryk Karkoszka | Zendy; David Kipgen | Zendy; Jagoda Małdyk | Zendy; Gianna Mazzucco | Zendy; Dıclehan Orhan | Zendy; Yasemin Özlük | Zendy; Afroditi Pantzaki | Zendy; Agnieszka PerkowskaPtasińska | Zendy; Zivili Riispere | Zendy; Magnus Söderberg | Zendy; Eric Steenbergen | Zendy; Antonella Stoppacciaro | Zendy; Birgitta Sundelin Von Feilitzen | Zendy; Regina Tardanico | Zendy

Open Access

Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort

Author(s) -

Shubha S. Bellur,

Stephen A. Roberts,

Stéphan Troyanov,

Virginie Royal,

Rosanna Coppo,

H. Terence Cook,

Daniel C. Cattran,

Y. Arce Terroba,

Anna Maria Asunis,

Ingeborg M. Bajema,

E. Bertoni,

Jan A. Bruijn,

Pablo CannataOrtiz,

Donatella Casartelli,

Anna Maria Di Palma,

Franco Ferrario,

Mirella Fortunato,

Luciana Furci,

Hariklia Gakiopoulou,

Danica Galešić Ljubanović,

Konstantinos Giannakakis,

Montserrat GomàiFreixanet,

Hermann-Josef Gröne,

Eduardo Gutiérrez,

Syeda Asma Haider,

Eva Honsová,

E. Ioachim,

Henryk Karkoszka,

David Kipgen,

Jagoda Małdyk,

Gianna Mazzucco,

Dıclehan Orhan,

Yasemin Özlük,

Afroditi Pantzaki,

Agnieszka PerkowskaPtasińska,

Zivili Riispere,

Magnus Söderberg,

Eric Steenbergen,

Antonella Stoppacciaro,

Birgitta Sundelin Von Feilitzen,

Regina Tardanico

Publication year - 2018

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfy337

Subject(s) - medicine , lesion , target lesion , nephropathy , biopsy , pathology , cohort , reproducibility , percutaneous coronary intervention , myocardial infarction , diabetes mellitus , endocrinology , statistics , mathematics

The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS.

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