Open AccessUrinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis
Author(s) -
Sarah Moran,
Paul A. Monach,
Lina Zgaga,
David Cuthbertson,
Simon Carette,
Nader Khalidi,
Curry L. Koening,
Carol A. Langford,
Carol A. McAlear,
Larry W. Moreland,
Christian Pagnoux,
Philip Seo,
Ulrich Specks,
Antoine G. Sreih,
Jason Wyse,
Steven R. Ytterberg,
Peter A. Merkel,
Mark A. Little
Publication year - 2018
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfy300
Subject(s) - medicine , vasculitis , creatinine , interquartile range , gastroenterology , anti neutrophil cytoplasmic antibody , urinary system , glomerulonephritis , immunology , pathology , kidney , disease
Prior work has shown that urinary soluble CD163 (usCD163) displays excellent biomarker characteristics for detection of active renal vasculitis using samples that included new diagnoses with highly active renal disease. This study focused on the use of usCD163 in the detection of the more clinically relevant state of mild renal flare and compared results of usCD163 testing directly to testing of urinary monocyte chemoattractant protein-1 (uMCP-1).