An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy | Zendy

Sang Youb Han | Zendy; Yi Hwa Jee | Zendy; Kum Hyun Han | Zendy; Young Sun Kang | Zendy; Hyoung Kyu Kim | Zendy; JeeYoung Han | Zendy; Young Sik Kim | Zendy; Dae Ryong | Zendy

Open Access

An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy

Author(s) -

Sang Youb Han,

Yi Hwa Jee,

Kum Hyun Han,

Young Sun Kang,

Hyoung Kyu Kim,

JeeYoung Han,

Young Sik Kim,

Dae Ryong

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl238

Subject(s) - endocrinology , medicine , tissue inhibitor of metalloproteinase , diabetic nephropathy , matrix metalloproteinase , angiotensin ii , streptozotocin , angiotensin ii receptor type 1 , renin–angiotensin system , receptor , context (archaeology) , kidney , downregulation and upregulation , diabetes mellitus , biology , biochemistry , paleontology , blood pressure , gene

High glucose and angiotensin-II (Ang-II) levels are the known important mediators of diabetic nephropathy. However, the effects of these mediators on matrix metalloproteinase-2 (MMP-2) and on tissue inhibitor of metalloproteinase-2 (TIMP-2) in proximal tubule cells have yet to be fully examined within the context of early stage diabetic nephropathy.

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