Open AccessIncreased dishevelled associated activator of morphogenesis 2, a new podocyte-associated protein, in diabetic nephropathy
Author(s) -
Chenyang Qi,
Faten Alsomali,
Jinyong Zhong,
Raymond C. Harris,
Valentina Kon,
Haichun Yang,
Agnes B. Fogo
Publication year - 2021
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfab014
Subject(s) - podocyte , wnt signaling pathway , medicine , endocrinology , diabetic nephropathy , gene knockdown , dishevelled , microbiology and biotechnology , mtorc1 , biology , kidney , signal transduction , pi3k/akt/mtor pathway , cell culture , proteinuria , frizzled , genetics
Previously, by using proteomic analysis and RNA sequencing in isolated glomeruli, we identified several novel differentially expressed proteins in human and mouse diabetic nephropathy (DN) versus controls, including dishevelled associated activator of morphogenesis 2 (DAAM2). DAAM2 binds the Wnt effector Dvl. We aimed to study possible contributions of DAAM2 to DN.