Open AccessClinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans
Author(s) -
Michael T. Eadon,
Sam Lampe,
M. Mansoor Baig,
Kimberly S. Collins,
Ricardo Melo Ferreira,
Henry Mang,
YingHua Cheng,
Daria Barwinska,
Tarek M. ElAchkar,
TaeHwi SchwantesAn,
Seth Winfree,
Constance J. Temm,
Michael J. Ferkowicz,
Kenneth W. Dunn,
Katherine J. Kelly,
Timothy A. Sutton,
Sharon M. Moe,
Ranjani N. Moorthi,
Carrie L. Phillips,
Pierre C. Dagher
Publication year - 2021
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfaa331
Subject(s) - medicine , pathology , laser capture microdissection , pathogenesis , biopsy , glomerulosclerosis , immunohistochemistry , proteinuria , nephropathy , diabetes mellitus , kidney , endocrinology , biology , gene expression , biochemistry , gene
Idiopathic nodular mesangial sclerosis, also called idiopathic nodular glomerulosclerosis (ING), is a rare clinical entity with an unclear pathogenesis. The hallmark of this disease is the presence of nodular mesangial sclerosis on histology without clinical evidence of diabetes mellitus or other predisposing diagnoses. To achieve insights into its pathogenesis, we queried the clinical, histopathologic and transcriptomic features of ING and nodular diabetic nephropathy (DN).