Open AccessAssociation of circulating cardiac biomarkers with electrocardiographic abnormalities in chronic kidney disease
Author(s) -
Alexander J. Kula,
Ronit Katz,
Leila R. Zelnick,
Elsayed Z Soliman,
Alan S. Go,
Michael G. Shlipak,
Rajat Deo,
Bonnie Ky,
Ian DeBoer,
Amanda Anderson,
R H Christenson,
Stephen L. Seliger,
Christopher deFilippi,
Harold I. Feldman,
Myles Wolf,
John W. Kusek,
Tariq Shafi,
Jiang He,
Nisha Bansal
Publication year - 2020
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfaa296
Subject(s) - medicine , cardiology , kidney disease , qt interval , atrial fibrillation , odds ratio , subclinical infection , renal function , troponin t , natriuretic peptide , qrs complex , risk factor , heart failure , myocardial infarction
Among patients with chronic kidney disease (CKD), the circulating cardiac biomarkers soluble ST2 (SST2), galectin-3, growth differentiation factor-15 (GDF-15), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin-T (hsTnT) possibly reflect pathophysiologic processes and are associated with clinical cardiovascular disease. Whether these biomarkers are associated with electrocardiographic findings is not known. The aim of this study was to test the association between serum cardiac biomarkers and the presence of electrocardiographic changes potentially indicative of subclinical myocardial disease in patients with CKD.