Open AccessImmunoglobulin G/albumin staining in tubular protein reabsorption droplets in minimal change disease and focal segmental glomerulosclerosis
Author(s) -
Lihong Bu,
James Mirocha,
Mark Haas
Publication year - 2020
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfaa039
Subject(s) - focal segmental glomerulosclerosis , medicine , minimal change disease , nephrotic syndrome , pathology , glomerulosclerosis , albumin , staining , immunoglobulin g , glomerulonephritis , antibody , kidney , proteinuria , immunology
Some renal biopsies cannot distinguish minimal change disease (MCD) from primary focal segmental glomerulosclerosis (FSGS) because of inadequate sampling and/or a lack of sampled glomeruli with segmental sclerosis. As protein excretion in MCD has been described as being albumin-selective, we examined whether the ratio of immunoglobulin G (IgG)/albumin staining in protein reabsorption droplets (tPRD) might help distinguish MCD from FSGS.