Sequence-selective fluorophore formation by furan-conjugated oligodeoxyribonucleotides | Zendy

Akio Kobori | Zendy; Jumpei Morita | Zendy; Masato Ikeda | Zendy; Asako Yamayoshi | Zendy; Akira Murakami | Zendy

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Sequence-selective fluorophore formation by furan-conjugated oligodeoxyribonucleotides

Author(s) -

Akio Kobori,

Jumpei Morita,

Masato Ikeda,

Asako Yamayoshi,

Akira Murakami

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn119

Subject(s) - fluorophore , conjugated system , furan , fluorescence , chemistry , sequence (biology) , oxidative phosphorylation , photochemistry , mutation , stereochemistry , biochemistry , gene , organic chemistry , physics , quantum mechanics , polymer

We developed a mutation diagnosis system using a 1,N'-ethenoadenosine forming reaction. Furan-derivatized oligodeoxyribonucleotides were synthesized and fluorescence properties were studied in the presence of complimentary strand under oxidative conditions. Strong emission at 430 nm was observed in the presence of A allele ODN.

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