Open AccessPSSweb: protein structural statistics web server
Author(s) -
Thomas Gaillard,
Roland H. Stote,
Annick Dejaegere
Publication year - 2016
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkw332
Subject(s) - web server , dihedral angle , protein data bank (rcsb pdb) , visualization , computer science , structural bioinformatics , biology , protein structure , cartesian coordinate system , protein data bank , structural biology , data mining , bioinformatics , the internet , mathematics , geometry , physics , genetics , hydrogen bond , biochemistry , quantum mechanics , molecule , world wide web
With the increasing number of protein structures available, there is a need for tools capable of automating the comparison of ensembles of structures, a common requirement in structural biology and bioinformatics. PSSweb is a web server for protein structural statistics. It takes as input an ensemble of PDB files of protein structures, performs a multiple sequence alignment and computes structural statistics for each position of the alignment. Different optional functionalities are proposed: structure superposition, Cartesian coordinate statistics, dihedral angle calculation and statistics, and a cluster analysis based on dihedral angles. An interactive report is generated, containing a summary of the results, tables, figures and 3D visualization of superposed structures. The server is available at http://pssweb.org.