Open AccessEMDataBank unified data resource for 3DEM
Author(s) -
Catherine L. Lawson,
Ardan Patwardhan,
Matthew L. Baker,
Corey F. Hryc,
Eduardo SanzGarcía,
Brian P. Hudson,
Ingvar Lagerstedt,
Steven J. Ludtke,
Grigore Pintilie,
Raul Sala,
John D. Westbrook,
Helen M. Berman,
Gerard J. Kleywegt,
Wah Chiu
Publication year - 2015
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkv1126
Subject(s) - metadata , biology , pipeline (software) , protein data bank , resource (disambiguation) , computational biology , computer science , data science , information retrieval , data mining , world wide web , protein structure , computer network , biochemistry , programming language
Three-dimensional Electron Microscopy (3DEM) has become a key experimental method in structural biology for a broad spectrum of biological specimens from molecules to cells. The EMDataBank project provides a unified portal for deposition, retrieval and analysis of 3DEM density maps, atomic models and associated metadata (emdatabank.org). We provide here an overview of the rapidly growing 3DEM structural data archives, which include maps in EM Data Bank and map-derived models in the Protein Data Bank. In addition, we describe progress and approaches toward development of validation protocols and methods, working with the scientific community, in order to create a validation pipeline for 3DEM data.
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