The Lipase Engineering Database: a navigation and analysis tool for protein families | Zendy

Markus Fischer | Zendy

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The Lipase Engineering Database: a navigation and analysis tool for protein families

Author(s) -

Markus Fischer

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkg015

Subject(s) - biology , computational biology , protein engineering , sequence database , sequence (biology) , sequence alignment , multiple sequence alignment , protein family , phylogenetic tree , function (biology) , structural alignment , sequence analysis , similarity (geometry) , protein sequencing , genetics , peptide sequence , enzyme , biochemistry , computer science , gene , artificial intelligence , image (mathematics)

The Lipase Engineering Database (LED) (http://www.led.uni-stuttgart.de) integrates information on sequence, structure, and function of lipases, esterases, and related proteins. Sequence data on 806 protein entries are assigned to 38 homologous families, which are grouped into 16 superfamilies with no global sequence similarity between each other. For each family, multisequence alignments are provided with functionally relevant residues annotated. Pre-calculated phylogenetic trees allow navigation inside superfamilies. Experimental structures of 45 proteins are superposed and consistently annotated. The LED has been applied to systematically analyze sequence-structure-function relationships of this vast and diverse enzyme class. It is a useful tool to identify functionally relevant residues apart from the active site residues, and to design mutants with desired substrate specificity.

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