A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains | Zendy

Arnold M Kiss | Zendy; Beáta E. Jády | Zendy; Xavier Darzacq | Zendy; Céline Verheggen | Zendy; Édouard Bertrand | Zendy; Tamás Kiss | Zendy

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A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains

Author(s) -

Arnold M Kiss,

Beáta E. Jády,

Xavier Darzacq,

Céline Verheggen,

Édouard Bertrand,

Tamás Kiss

Publication year - 2002

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkf592

Subject(s) - pseudouridine , small nuclear rna , small nucleolar rna , cajal body , biology , rna , guide rna , ribosomal rna , non coding rna , genetics , computational biology , microbiology and biotechnology , transfer rna , gene , genome , rna splicing , cas9

Site-specific post-transcriptional conversion of uridines to pseudouridine in ribosomal RNAs and small nuclear RNAs (snRNAs) is directed by guide RNAs which possess the conserved box H and ACA sequence elements and fold into the consensus 'hairpin-hinge-hairpin-tail' secondary structure. Here, we describe an unusual mammalian pseudouridylation guide RNA, called U93, that is composed of two tandemly arranged box H/ACA RNA domains. The U93 RNA therefore carries two H and two ACA box motifs, all of which are essential for accumulation of the full-length RNA. The human U93 RNA accumulates in Cajal (coiled) bodies and it is predicted to function in pseudouridylation of the U2 spliceosomal snRNA. Our results lend further support to the notion that modification of the RNA polymerase II-transcribed spliceosomal snRNAs takes place in Cajal bodies.

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