Open AccessUntangling the crosstalk between BRCA1 and R-loops during DNA repair
Author(s) -
Marta San Martín Alonso,
Sylvie M. Noordermeer
Publication year - 2021
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkab178
Subject(s) - biology , dna repair , dna , crosstalk , microbiology and biotechnology , context (archaeology) , genetics , genome instability , dna damage , computational biology , physics , paleontology , optics
R-loops are RNA:DNA hybrids assembled during biological processes but are also linked to genetic instability when formed out of their natural context. Emerging evidence suggests that the repair of DNA double-strand breaks requires the formation of a transient R-loop, which eventually must be removed to guarantee a correct repair process. The multifaceted BRCA1 protein has been shown to be recruited at this specific break-induced R-loop, and it facilitates mechanisms in order to regulate R-loop removal. In this review, we discuss the different potential roles of BRCA1 in R-loop homeostasis during DNA repair and how these processes ensure faithful DSB repair.