Bulges in left-handed G-quadruplexes | Zendy

Poulomi Das | Zendy; Khac Huy Ngo | Zendy; Fernaldo Richtia Winnerdy | Zendy; Arijit Maity | Zendy; Blaž Bakalar | Zendy; Yves Mechulam | Zendy; Emmanuelle Schmitt | Zendy; Anh Tuân Phan | Zendy

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Bulges in left-handed G-quadruplexes

Author(s) -

Poulomi Das,

Khac Huy Ngo,

Fernaldo Richtia Winnerdy,

Arijit Maity,

Blaž Bakalar,

Yves Mechulam,

Emmanuelle Schmitt,

Anh Tuân Phan

Publication year - 2020

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkaa1259

Subject(s) - biology , left handed , g quadruplex , genetics , computational biology , evolutionary biology , dna , physics , optics

G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.

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