Correlation between the presence of tRNAHisGUGand the erythropoietic function in foetal sheep liver | Zendy

R.M. Landin | Zendy; Monique Boisnard | Zendy; Guy Pétrissant | Zendy

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Correlation between the presence of tRNA^His_GUGand the erythropoietic function in foetal sheep liver

Author(s) -

R.M. Landin,

Monique Boisnard,

Guy Pétrissant

Publication year - 1979

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/7.6.1635

Subject(s) - biology , transfer rna , function (biology) , genetics , biochemistry , rna , gene

Histidyl-tRNAs from foetal and adult sheep liver were compared to their reticulocyte counterparts. The combination of various techniques revealed the existence of two histidyl-tRNA species in reticulocytes, one of which was not retained on acetylated DBAE-cellulose columns and was guanylatable. Three histidyl-tRNA isoacceptors were identified in foetal liver. Two of these species were not adsorbed on acetylated DBAE-cellulose but only one was found to be guanylatable. An identical chromatographic behaviour on RPC-5 columns was observed for guanylated histidyl-tRNAs from both origins. These results suggest the occurrence of a GUG anticodon in these guanine-accepting tRNAs. In foetal liver the amount of guanylatable histidyl-tRNA was estimated to be 7% of the total tRNA population. This observation is in agreement with the erythropoietic function of liver during the foetal life.

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