Open AccessThe molecular electrostatic potential of the B-DNA helix. VL The regions of the base pairs in poly (dG.dC) and poly (dA.dT)
Author(s) -
Bernard Pullman,
David Pérahia,
Didier Cauchy
Publication year - 1979
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/6.12.3821
Subject(s) - polynucleotide , biology , dna , nucleotide , base pair , helix (gastropod) , pyrimidine , stereochemistry , biochemistry , chemistry , gene , ecology , snail
The evaluation of the electrostatic molecular potential at important nucleophilic sites of the purine and pyrimidine bases in poly (dG.dC) and poly (dA.dT) and of the evolution of the potential through the series free bases-nucleosides-nucleotides-single polynucleotide helices-double helices enables the interpretation of the evolution of the corresponding reactivity of the bases towards a series of electrophilic carcinogenic and mutagenic reactants.