Photosensitization of DNA by gold | Zendy

R.J. Wilkins | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Photosensitization of DNA by gold

Author(s) -

R.J. Wilkins

Publication year - 1978

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/5.10.3731

Subject(s) - pyrimidine dimer , cyclobutane , dna , biology , cytosine , adduct , photochemistry , thymine , pyrimidine , nucleobase , excited state , biophysics , dna repair , biochemistry , chemistry , organic chemistry , ring (chemistry) , physics , nuclear physics

Au (III) reacts with DNA at pH 5.6 to form a complex which is sensitive to mid-UV radiation. Cyclobutane pyrimidine dimers are produced at some 15 to 30 times the rate that they are in untreated DNA. The mechanism of photosensitization appears to involve energy absorption by Au-urine and Au-cytosine adducts which can then transfer energy to thymine residues. There is no evidence for a "heavy atom" effect which enables metals such as Ag to mix excited states of DNA and to increase the quantum yields of some photoproducts. The use of mid-UV radiation as a probe for investigating the interaction between DNA and drugs such as sodium aurothiomalate is discussed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research