Open AccessA31P - NMR study of the interaction of Mg2+ions with nucleoside diphosphates
Author(s) -
S. Tran-Dinh,
JeanMichel Neumann
Publication year - 1977
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/4.2.397
Subject(s) - nucleoside , biology , ion , von neumann architecture , library science , physics , genetics , mathematics , computer science , quantum mechanics , pure mathematics
The interaction of Mg2+ with nucleoside disphosphates : ADP, GDP, CDP and UDP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution. The results show that these four nucleotides behave similarly, the Mg2+ ion binds to the alpha but not to the beta phosphate moiety. The strength of the interaction of Mg2+ ions with nucleoside diphosphates is weaker than with nucleoside triphosphates. The association of Mg2+ on the phosphate chain is stronger in a neutral than in an acid medium.