Subunit associations among chromatin particles | Zendy

Ailsa M. Campbell | Zendy; Rosalind I. Cotter | Zendy

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Subunit associations among chromatin particles

Author(s) -

Ailsa M. Campbell,

Rosalind I. Cotter

Publication year - 1977

Publication title -

nucleic acids research

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/4.11.3877

Subject(s) - biology , chromatin , histone , magnesium , protein subunit , nucleosome , biophysics , sodium , biochemistry , dna , chemistry , gene , organic chemistry

The self-association of oligonucleosomal chromatin particles in solution has been studied by light scattering and sedimentation. In the absence of magnesium ions no association is observed. In the presence of 70mM sodium or 2mM magnesium ions mono, di, tri and tetranucleosomes self-associate only if they contain bound histone 1. This association leads to the formation of compact aggregates and is continuous and non-cooperative. The relevance to higher order arrangements of nucleosomes is discussed.

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