Variation in DNA swivel enzyme activity during the mammalian cell cycle | Zendy

Barbara Hatch Rosenberg | Zendy; Grace E. Ungers | Zendy; J.F. Deutsch | Zendy

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Variation in DNA swivel enzyme activity during the mammalian cell cycle

Author(s) -

Barbara Hatch Rosenberg,

Grace E. Ungers,

J.F. Deutsch

Publication year - 1976

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/3.12.3305

Subject(s) - biology , enzyme , dna replication , dna , cell cycle , enzyme assay , activator (genetics) , population , cell culture , dna synthesis , endogeny , microbiology and biotechnology , biochemistry , cell , genetics , gene , demography , sociology

Synchronized cells of a normal human lymphocytic cell line contain little swiven enzyme activity in G0 and G1 and high activity in Sphase. The level of activity in different growth phase appears to be related to the fraction of the population engaged in DNA replication. No endogenous inhibitor or activator of swiven activity could be demonstrated. The evidence implies that the enzyme may be present only during S phase; it is therefore a possible control factor for replication.

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