Open AccessSURVEY AND SUMMARY: Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit
Author(s) -
Ivaylo P. Ivanov,
Raymond F. Gesteland,
John F. Atkins
Publication year - 2000
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/28.17.3185
Subject(s) - biology , ornithine decarboxylase antizyme , frameshift mutation , translational frameshift , schizosaccharomyces pombe , genetics , phenocopy , ribosome , microbiology and biotechnology , conserved sequence , gene , rna , mutation , saccharomyces cerevisiae , base sequence , biochemistry , ornithine decarboxylase , mutant , enzyme
The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.