SURVEY AND SUMMARY: Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit | Zendy

Ivaylo P. Ivanov | Zendy

Open Access

SURVEY AND SUMMARY: Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit

Author(s) -

Ivaylo P. Ivanov

Publication year - 2000

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/28.17.3185

Subject(s) - biology , ornithine decarboxylase antizyme , frameshift mutation , translational frameshift , schizosaccharomyces pombe , genetics , phenocopy , ribosome , microbiology and biotechnology , conserved sequence , gene , rna , mutation , saccharomyces cerevisiae , base sequence , biochemistry , ornithine decarboxylase , mutant , enzyme

The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.

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