Isoguanine Quartets Formed by d(T4isoG4T4): Tetraplex Identification and Stability | Zendy

Frank Seela | Zendy; Changfu Wei | Zendy; Alexander Melenewski | Zendy

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Isoguanine Quartets Formed by d(T4isoG4T4): Tetraplex Identification and Stability

Author(s) -

Frank Seela,

Changfu Wei,

Alexander Melenewski

Publication year - 1996

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/24.24.4940

Subject(s) - monomer , high performance liquid chromatography , sodium , chromatography , oligonucleotide , biology , ion , analytical chemistry (journal) , polymer , biochemistry , chemistry , dna , organic chemistry

The self-aggregation of the oligonucleotide d(T4isoG4T4) (1) is investigated. Based on ion exchange HPLC experiments and CD spectroscopy, a tetrameric structure is identified. This structure was formed in the presence of sodium ions and shows almost the same chromatographic mobility on ion exchange HPLC as d(T4G4T4) (2). The ratio of aggregate versus monomer is temperature dependent and the tetraplex of [d(T4isoG4T4)]4 is more stable than that of [d(T4G4T4)]4. A mixture of d(T4isoG4T4) and d(T4G4T4) forms mixed tetraplexes containing strands of d(T4isoG4T4) and d(T4G4T4).

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