The P1 family: a new class of nuclear mammalian proteins related to the yeast Mem replication proteins | Zendy

Bing Hu | Zendy; Roland Burkhart | Zendy; Dorothea Schulte | Zendy; Christine Musahl | Zendy; Rolf Knippers | Zendy

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The P1 family: a new class of nuclear mammalian proteins related to the yeast Mem replication proteins

Author(s) -

Bing Hu,

Roland Burkhart,

Dorothea Schulte,

Christine Musahl,

Rolf Knippers

Publication year - 1993

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/21.23.5289-a

Subject(s) - biology , saccharomyces cerevisiae , yeast , schizosaccharomyces pombe , complementary dna , cdna library , genetics , nuclear protein , conserved sequence , dna replication , peptide sequence , schizosaccharomyces , microbiology and biotechnology , dna , gene , transcription factor

Monospecific antibodies against an oligopeptide, conserved among the Mcm class of yeast replication proteins, were used to screen a human cDNA library. Eight of the isolated cDNA clones have the potential to code for sections of proteins with high sequence similarities to the yeast proteins Mcm3 and Cdc46 from Saccharomyces cerevisiae and Cdc21 from S. pombe. Our results establish a novel and highly conserved family of nuclear proteins in mammalian cells.

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